17β-Estradiol Inhibits the Production of RANTES in Human Keratinocytes
March 2003
in “
Journal of Investigative Dermatology
”
17β-estradiol RANTES human keratinocytes TNF-α IL-1β psoriatic skin lesions estrogen receptors nuclear factor κB NF-κB estrogen receptor antagonist ICI 182 780 CREB NF-κB p65 CREB-binding protein E2 tumor necrosis factor alpha interleukin-1 beta psoriasis estrogen receptor nuclear factor kappa B cyclic AMP response element-binding protein
TLDR 17β-estradiol can reduce inflammation in the skin.
The study concluded that 17β-estradiol (E2) inhibited the production of the chemokine RANTES in human keratinocytes, which is significant for inflammatory responses in conditions like psoriasis. E2 suppressed RANTES secretion, mRNA expression, and promoter activity induced by TNF-α or IL-1β through estrogen receptor-mediated mechanisms involving the suppression of NF-κB transcriptional activity. The findings suggested that E2 could potentially modulate inflammatory skin diseases by affecting chemokine production, highlighting its potential therapeutic use for psoriasis treatment.
