17β-Estradiol Inhibits the Production of RANTES in Human Keratinocytes

    March 2003 in “ Journal of Investigative Dermatology ”
    Naoko Kanda, Shinichi Watanabe
    TLDR 17β-estradiol can reduce inflammation in the skin.
    The study concluded that 17β-estradiol (E2) inhibited the production of the chemokine RANTES in human keratinocytes, which is significant for inflammatory responses in conditions like psoriasis. E2 suppressed RANTES secretion, mRNA expression, and promoter activity induced by TNF-α or IL-1β through estrogen receptor-mediated mechanisms involving the suppression of NF-κB transcriptional activity. The findings suggested that E2 could potentially modulate inflammatory skin diseases by affecting chemokine production, highlighting its potential therapeutic use for psoriasis treatment.
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