February 2023 in “Journal of Drugs in Dermatology” In this literature review, researchers found evidence that topical melatonin may improve scalp hair growth, density, and thickness in patients with androgenetic alopecia, especially in men.
14 citations
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December 2021 in “International journal of molecular sciences” This article reviews current knowledge and research gaps on growth hormone in hair follicle biology, highlighting its complex role and suggesting further exploration to reveal nonclassical skin functions.
50 citations
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November 2021 in “Viruses” This study observed that in vitro exposure to dihydrotestosterone worsened COVID-19 spike protein-induced endothelial injury, while spironolactone showed potential in reducing this effect, suggesting a rationale for further evaluation in treating COVID-19.
102 citations
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July 2020 in “International journal of molecular sciences” This review discusses the effects of hormonal changes on hair follicles, concluding that hormones like androgens and estradiol significantly influence hair growth and cycle, while the roles of other hormones are still being researched.
24 citations
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June 2018 in “PubMed” This study found that liposterolic extracts of Serenoa repens enhanced hair regeneration and repair in DHT-induced hair loss mouse models, suggesting potential effects comparable to finasteride.
29 citations
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August 2017 in “Skin appendage disorders” This study found that IGF-1 likely plays a crucial role in regulating hair growth and alopecia, with balding scalp follicles secreting less IGF-1 than nonbalding counterparts.
12 citations
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December 2016 in “PubMed” This review discusses causes, diagnostic guidelines, and management strategies for hirsutism, highlighting the need for appropriate evaluations and treatment considerations in different patient populations, but reports no new clinical results.
34 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that androgens influence hair follicle behavior via the dermal papilla, using evidence from human and red deer cells with differing androgen responses as models.
34 citations
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December 1991 in “Annals of the New York Academy of Sciences” This study found that while the steroid mechanisms influencing androgenetic alopecia may be similar for men and women, differences in enzyme activity and receptor content could explain their varied clinical presentations.