SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism

    November 2021 in “ Viruses ”
    Nitin Kumar, Yu Zuo, Srilakshmi Yalavarthi … Santhi K. Ganesh
    Studysummary This study observed that in vitro exposure to dihydrotestosterone worsened COVID-19 spike protein-induced endothelial injury, while spironolactone showed potential in reducing this effect, suggesting a rationale for further evaluation in treating COVID-19.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 6

    1. Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial Cureus · 2021
    2. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020
    3. Sex Differences in SARS-CoV-2 Infection Rates and the Potential Link to Prostate Cancer Communications biology · 2020
    4. Evidence-Based Approach to Cutaneous Hyperandrogenism in Women Journal of The American Academy of Dermatology · 2015
    5. Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss PubMed · 2010
    6. Natural Potent Androgens: Lessons from Human Genetic Models Baillière s Clinical Endocrinology and Metabolism · 1998