Association Between Mineralocorticoid Receptor Antagonist and Mortality in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis

    March 2022 in “ Healthcare ”
    Jean Kim, Kyle Miyazaki, Parthav Shah, Landon Kozai, Jakrin Kewcharoen
    TLDR Mineralocorticoid receptor antagonist therapy does not significantly reduce mortality in COVID-19 patients.
    This systematic review and meta-analysis investigated the association between mineralocorticoid receptor antagonist (MRA) therapy and mortality in SARS-CoV-2 patients. The study included five studies with a total of 1,388,178 subjects, of which 80,903 were receiving MRA therapy. Despite the proposed protective effects of MRAs, such as spironolactone, against SARS-CoV-2 infection, the analysis found no significant association between MRA therapy and reduced mortality in these patients (OR = 0.387, 95% CI: 0.134–1.117, p = 0.079).
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