Roles of Steroid Receptors in the Lung and COVID-19

    July 2021 in “ Essays in Biochemistry ”
    Damien A. Leach, Greg N. Brooke, Charlotte Bevan
    Studysummary This review discusses the roles of steroid hormone receptors in lung function related to COVID-19 and outlines ongoing clinical trials of steroid receptor ligands, but reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells Nature Communications · 2021
    2. Sex- Or Gender-Specific Differences In The Clinical Presentation, Outcome, And Treatment Of SARS-CoV-2 Clinical Therapeutics · 2021
    3. Alert to US Physicians: DHEA, Widely Used as an OTC Androgen Supplement, May Exacerbate COVID-19 Endocrine-related Cancer · 2020
    4. Androgenetic Alopecia May Be Associated With Weaker COVID-19 T-Cell Immune Response: An Insight Into a Potential COVID-19 Vaccine Booster Medical Hypotheses · 2020
    5. Sex Differences in COVID-19: The Role of Androgens in Disease Severity and Progression Endocrine · 2020
    6. Androgenetic Alopecia in COVID-19: Comparison to Age-Matched Epidemiologic Studies and Hospital Outcomes With or Without the Gabrin Sign Journal of The American Academy of Dermatology · 2020
    7. Male Balding Is a Major Risk Factor for Severe COVID-19 Journal of The American Academy of Dermatology · 2020
    8. Androgenetic Alopecia Present in the Majority of Patients Hospitalized with COVID-19: The 'Gabrin Sign' Journal of The American Academy of Dermatology · 2020
    9. A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity Journal of Cosmetic Dermatology · 2020
    10. Anti-Androgen Hormonal Therapy for Cancer and Other Diseases European Journal of Pharmacology · 2019
    11. Gender Differences in the Regulation of Blood Pressure Hypertension · 2001