The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells

    July 2021 in “ Nature Communications ”
    Damien A. Leach, Andrea Mohr, Efstathios S. Giotis … Greg N. Brooke
    Studysummary This study found that the antiandrogen drug enzalutamide reduced TMPRSS2 levels and significantly decreased SARS-CoV-2 entry and infection in lung cells, supporting further clinical trials for COVID-19 treatment.
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    Research cited in this study 7

    1. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020
    2. Androgenetic Alopecia Present in the Majority of Patients Hospitalized with COVID-19: The 'Gabrin Sign' Journal of The American Academy of Dermatology · 2020
    3. Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti-Androgens a Potential Treatment for COVID-19? Journal of Cosmetic Dermatology · 2020
    4. A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity Journal of Cosmetic Dermatology · 2020
    5. Anti-Androgen Hormonal Therapy for Cancer and Other Diseases European Journal of Pharmacology · 2019
    6. Cause of Androgenic Alopecia Plastic and reconstructive surgery. Global open · 2013
    7. Visualizing Androgen Receptor Activity in Male and Female Mice PloS one · 2013

    Related research 3

    1. Latent Hazard in Prostate Cancer and Benign Prostatic Hyperplasia Patients Referred to Antiandrogens: Prostate Cancer Aggressiveness and Neuroendocrine Differentiation Anticancer Research · 2004
    2. Topical Antiandrogens in the Treatment of Male-Pattern Baldness Clinics in dermatology · 1988
    3. Pharmacology of Antiandrogens Journal of Steroid Biochemistry · 1986