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GlossaryAngiotensin-Converting Enzyme 2 (ACE2 receptor)

regulates blood pressure and is a SARS-CoV-2 entry point

Angiotensin-Converting Enzyme 2 (ACE2) is a protein found on the surface of many cell types, including those in the lungs, heart, and kidneys. It plays a crucial role in regulating blood pressure by converting angiotensin II, a molecule that can increase blood pressure, into angiotensin 1-7, which has the opposite effect. ACE2 is also known for being the entry point for the SARS-CoV-2 virus, which causes COVID-19, making it a significant focus of medical research.

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research A Response to 'Male Balding Is a Major Risk Factor for Severe COVID-19'

2 citations , October 2020 in “Journal of The American Academy of Dermatology”

The authors suggest that scalp hair might protect against COVID-19 and call for more research on scalp health and the virus.

Are the Cutaneous Manifestations During or Due to SARS-CoV-2 Infection/COVID-19 Frequent or Not? Revision of Possible Pathophysiologic Mechanisms

research Are the Cutaneous Manifestations During or Due to SARS-CoV-2 Infection/COVID-19 Frequent or Not? Revision of Possible Pathophysiologic Mechanisms

82 citations , June 2020 in “Inflammation Research”

Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.

research Insights Into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity

February 2023 in “Vaccines”

COVID-19 may harm male reproductive health and lower testosterone levels, potentially affecting fertility and causing erectile dysfunction. More research is needed.

research Basic Mechanisms of SARS-CoV-2 Infection: Implications for Endocrine Systems

14 citations , July 2021 in “Reviews in endocrine and metabolic disorders”

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

research The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells

50 citations , July 2021 in “Nature Communications”

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

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community Adrogens and Covid-19

in Treatment 7 upvotes 5 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.