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GlossaryTMPRSS2

enzyme aiding viral entry into human cells

TMPRSS2 stands for Transmembrane Serine Protease 2, an enzyme that plays a role in the activation of certain proteins by cutting them at specific sites. It is notably involved in the process by which the SARS-CoV-2 virus, responsible for COVID-19, enters human cells, making it a target for therapeutic interventions.

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research The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells

50 citations , July 2021 in “Nature Communications”

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

research ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-CoV-2 in Cancer Patients

38 citations , January 2020 in “Cell Transplantation”

Targeting ACE2 and TMPRSS2 may help prevent or treat COVID-19 in cancer patients.

research Spiking Dependence of SARS-CoV-2 Pathogenicity on TMPRSS2

30 citations , February 2021 in “Journal of Medical Virology”

TMPRSS2 affects COVID-19 severity and treatment options.

research The Secret Identities of TMPRSS2: Fertility Factor, Virus Trafficker, Inflammation Moderator, Prostate Protector and Tumor Suppressor

16 citations , August 2021 in “Tumor Biology”

TMPRSS2 helps viruses enter cells and protects the prostate from inflammation-related cancer.

research TMPRSS2, Required for SARS-CoV-2 Entry, Is Downregulated in Lung Cells by Enzalutamide, a Prostate Cancer Therapeutic

2 citations , June 2020 in “Research Square (Research Square)”

A prostate cancer drug can lower the levels of a protein that the coronavirus uses to enter lung cells.

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community Adrogens and Covid-19

in Treatment 7 upvotes 5 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.