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GlossaryTMPRSS2

enzyme aiding viral entry into human cells

TMPRSS2 stands for Transmembrane Serine Protease 2, an enzyme that plays a role in the activation of certain proteins by cutting them at specific sites. It is notably involved in the process by which the SARS-CoV-2 virus, responsible for COVID-19, enters human cells, making it a target for therapeutic interventions.

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research An Assessment on the Impact of COVID-19 Infection in a Gender-Specific Manner

59 citations , October 2020 in “Stem Cell Reviews and Reports”

Men have higher COVID-19 mortality rates than women due to biological and lifestyle factors.

research COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine

58 citations , December 2020 in “Mayo Clinic Proceedings”

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Male Balding as a Major Risk Factor for Severe COVID-19: A Possible Role for Targeting Androgens and Transmembrane Protease Serine 2 to Protect Vulnerable Individuals

research Male Balding as a Major Risk Factor for Severe COVID-19: A Possible Role for Targeting Androgens and Transmembrane Protease Serine 2 to Protect Vulnerable Individuals

6 citations , September 2020 in “Journal of The American Academy of Dermatology”

Severe male balding may increase the risk of serious COVID-19, and treatments that reduce androgens or block a specific enzyme might help protect these individuals.

research TMPRSS2, Required for SARS-CoV-2 Entry, Is Downregulated in Lung Cells by Enzalutamide, a Prostate Cancer Therapeutic

2 citations , June 2020 in “Research Square (Research Square)”

A prostate cancer drug can lower the levels of a protein that the coronavirus uses to enter lung cells.

research The Immune Response to COVID-19: Does Sex Matter?

15 citations , April 2022 in “Immunology”

Men and women get COVID-19 at similar rates, but men tend to get sicker and have a higher risk of dying, while women usually have stronger immune responses and vaccine reactions.

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community Adrogens and Covid-19

in Treatment 6 upvotes 5 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.