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    Glossary TMPRSS2

    enzyme aiding viral entry into human cells

    TMPRSS2 stands for Transmembrane Serine Protease 2, an enzyme that plays a role in the activation of certain proteins by cutting them at specific sites. It is notably involved in the process by which the SARS-CoV-2 virus, responsible for COVID-19, enters human cells, making it a target for therapeutic interventions.

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    Research 30 of 298

    1. The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells Nature Communications · 2021 · 50 citations
    2. ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients Cell Transplantation · 2020 · 38 citations
    3. The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor Tumor Biology · 2021 · 16 citations
    4. Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury Scientific Reports · 2021 · 5 citations
    5. TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target Medeniyet Medical Journal · 2025 · 4 citations
    6. TMPRSS2, required for SARS-CoV-2 entry, is downregulated in lung cells by enzalutamide, a prostate cancer therapeutic Research Square (Research Square) · 2020 · 2 citations
    7. Enzalutamide, a prostate cancer therapeutic, downregulates TMPRSS2 in lung and reduces cellular entry of SARS-CoV-2 Research Square (Research Square) · 2021 · 1 citations
    8. Vitamin D And Tmprss2: Intersecting Pathways In Post-Covid-19 Alopecia Journal of Contemporary Medicine · 2026
    9. Finasteride Induces Epigenetic Alteration of TMPRss2 Gene Expression: A Potential role in Severe Acute Respiratory Syndrome-Corona Virus-2 Inhibition 2023
    10. The Mask Mutation Identifies TMPRSS6 as an Essential Suppressor of Hepcidin Gene Expression, Required for Normal Uptake of Dietary Iron. Blood · 2007 · 9 citations
    11. Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2 Journal of Medical Virology · 2021 · 30 citations
    12. Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies European Journal of Clinical Pharmacology · 2020 · 77 citations
    13. Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity Human Genomics · 2023 · 9 citations
    14. Is COVID-19 Gender-sensitive? Journal of Neuroimmune Pharmacology · 2021 · 228 citations
    15. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer 2013 · 224 citations
    16. Cutaneous signs in COVID ‐19 patients: A review Dermatologic Therapy · 2020 · 176 citations
    17. Androgen sensitivity gateway to COVID‐19 disease severity Drug Development Research · 2020 · 123 citations
    18. Sex differences in COVID-19: the role of androgens in disease severity and progression Endocrine · 2020 · 121 citations
    19. Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms Inflammation Research · 2020 · 82 citations
    20. Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature Dermatopathology · 2020 · 80 citations
    21. An Assessment on Impact of COVID-19 Infection in a Gender Specific Manner Stem Cell Reviews and Reports · 2020 · 59 citations
    22. COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine Mayo Clinic Proceedings · 2020 · 58 citations
    23. Are sex discordant outcomes in COVID-19 related to sex hormones? Seminars in Oncology · 2020 · 42 citations
    24. The role of androgens in COVID-19 Diabetes and Metabolic Syndrome: Clinical Research and Reviews · 2020 · 40 citations
    25. Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia International Journal of Infectious Diseases · 2021 · 38 citations
    26. Redefining hormone resistance in prostate cancer Therapeutic Advances in Medical Oncology · 2009 · 38 citations
    27. Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Frontiers in Medicine · 2020 · 36 citations
    28. Repurposing existing drugs for COVID-19: an endocrinology perspective BMC Endocrine Disorders · 2020 · 34 citations
    29. Relationship between betacoronaviruses and the endocrine system: a new key to understand the COVID-19 pandemic—A comprehensive review Journal of Endocrinological Investigation · 2021 · 23 citations
    30. Testosterone target therapy: focus on immune response, controversies and clinical implications in patients with COVID-19 infection Therapeutic Advances in Endocrinology and Metabolism · 2021 · 21 citations