Genetic and Hormonal Influence on SARS-CoV-2 Infection Susceptibility

    October 2020 in “ Annals of Oncology ”
    Monica Montopoli, Sara Zumerle, Massimo Rugge, Andrea Alimonti
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    TLDR Men may be more vulnerable to severe COVID-19 due to genetic and hormonal factors, but more research is needed.
    The document discussed the potential genetic and hormonal influences on susceptibility to SARS-CoV-2 infection, particularly focusing on the differences in COVID-19 outcomes between genders. It highlighted that men were more vulnerable to severe outcomes, possibly due to male hormones and genetic factors such as Y chromosome polymorphisms. The study analyzed SARS-CoV-2-infected prostate cancer patients in Italy and suggested that androgen receptor (AR) gene variants might play a role, although a direct link to COVID-19 severity was not established. Additionally, the document mentioned the importance of ACE2 and TMPRSS2 genes, which are crucial for viral entry, and their genetic variants that might explain sex-related differences in disease severity. However, it concluded that more extensive studies were needed to confirm the role of genetic modulators in COVID-19 outcomes.
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