Immunoreactivity of the SARS-CoV-2 Entry Proteins ACE-2 and TMPRSS-2 in Murine Models of Hormonal Manipulation, Aging, and Cardiac Injury

December 2021 in “ Scientific Reports ”

Susan Bengs, Alexia Rossi, Martina Haberecker, Nidaa Mikaïl, Alexander Meisel, Ahmed Haider, Muriel Grämer, Angela Portmann, Atanas Todorov, Christof Schönenberger, Caroline E. Gebhard, Gabriela M. Kuster, Vera Regitz‐Zagrosek, Cathérine Gebhard

sex hormones gonadal hormones ACE-2 TMPRSS-2 myocardial injury cardiovascular disease pulmonary expression immune status COVID-19 mortality heart attack heart disease lung expression immune system COVID-19 death rate

Studysummary In this study, researchers found that in mice, gonadal hormones and biological sex do not affect the expression of SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in the respiratory tract, regardless of disease state.

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