5 citations
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December 2021 in “Scientific Reports” In this study, researchers found that in mice, gonadal hormones and biological sex do not affect the expression of SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in the respiratory tract, regardless of disease state.
38 citations
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January 2020 in “Cell Transplantation” This study found that ACE2 and TMPRSS2 genes were more highly expressed in tumors of elderly male cancer patients compared to healthy individuals, with notable differences across age and gender.
6 citations
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May 2021 in “Clinical Chemistry and Laboratory Medicine” This review discusses the impact of ACE polymorphism on COVID-19 severity, suggesting it affects adults more than children, but presents mixed findings concerning infection prevalence and mortality.
2 citations
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July 2024 in “Ibn AL- Haitham Journal For Pure and Applied Science” This study found that PCOS women with COVID-19 had lower ACE2 levels and higher insulin resistance, suggesting increased cardiovascular risk.
1 citations
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January 2025 in “Journal of Cosmetic Dermatology” This study found that increased ACE2 expression, prompted by mechanical stretch, promotes skin regeneration and reduces dermal thinning during tissue expansion by enhancing collagen synthesis, suggesting ACE2's potential to improve clinical outcomes in reconstructive surgery settings.