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Glossary Renin-Angiotensin System

hormone system regulating blood pressure and fluid balance

The Renin-Angiotensin System (RAS), also known as the Renin-Angiotensin-Aldosterone System (RAAS), is a hormone system that regulates blood pressure and fluid balance in the body. When blood pressure drops, the kidneys release the enzyme renin, which triggers a cascade of reactions leading to the production of angiotensin II, a potent vasoconstrictor that increases blood pressure and stimulates the release of aldosterone from the adrenal glands, promoting sodium and water retention.

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research Studying the correlation of renin-angiotensin-system (RAS) components and insulin resistance in polycystic ovary syndrome (PCOs)

12 citations , March 2013 in “Gynecological Endocrinology”

This study found that women with PCOS had significantly higher angiotensin converting enzyme activity and insulin resistance compared to controls, suggesting a correlation between these factors.

research A perspective on small molecules targeting the renin–angiotensin–aldosterone system and their utility in cardiovascular diseases: exploring the structural insights for rational drug discovery and development

6 citations , January 2025 in “RSC Medicinal Chemistry”

This review discusses the signaling mechanisms of RAAS, the current drugs targeting RAAS, their limitations, and suggests innovative strategies for developing new therapeutics but reports no new results.

research The Immun System Response İn Covıd-19 Infectıon İn Polycystıc Ovary Syndrome

1 citations , May 2021 in “International Journal Of Medical Science And Clinical Invention”

This review discusses the potential risk mechanisms for COVID-19 in women with polycystic ovarian syndrome due to hyperandrogenism and calls for further research, but reports no new findings.

research Commonalities Between COVID-19 and Radiation Injury

18 citations , October 2020 in “Radiation Research”

This review discusses the similarities between COVID-19 and acute radiation syndrome, highlighting their shared inflammatory responses and suggesting that insights from radiation biology could inform COVID-19 research and treatment approaches; it reports no new clinical results.

research Molecular Mechanisms Lead to Sex-Specific COVID-19 Prognosis and Targeted Therapies

10 citations , December 2020 in “Frontiers in Medicine”

This review discusses the molecular differences between male and female responses to SARS-CoV-2 infection and highlights the lack of specific guidelines for altering sex-specific COVID-19 prognoses.

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community Being Safe on Oral Minoxidil: tl;dr on the literature.

51 upvotes 1 year ago

Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

community The Biggest Concern That I Have For Oral Minoxidil: Cardiac Hypertrophy

26 upvotes 3 years ago

Oral minoxidil can cause serious heart issues like cardiac hypertrophy and arrhythmias, prompting some users to reduce dosage or switch to topical treatments. Despite significant hair regrowth, side effects such as shortness of breath and chest pains are common concerns.

community P-1075: a BETTER version of Minoxidil

11 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Oral Minoxidil and the "Facial Bloating" - what the research actually says

43 upvotes 4 months ago

Oral minoxidil can cause rare facial bloating, especially at higher doses and in women. Reducing sodium intake, drinking more water, and adjusting the dose can help manage side effects.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 year ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

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