Increased Plasma Renin by Vasodilators Promotes the Progression of Abdominal Aortic Aneurysm

    June 2023 in “ Frontiers in Pharmacology ”
    Yu Liu, Shuai Liu, Jiani Zhao … Wei Wang
    Studysummary This study found that hydralazine and minoxidil, two direct vasodilators, may worsen abdominal aortic aneurysm progression by increasing aortic degeneration and inflammation.
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    Research cited in this study 8

    1. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    2. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    3. Minoxidil Improves Vascular Compliance, Restores Cerebral Blood Flow, and Alters Extracellular Matrix Gene Expression in a Model of Chronic Vascular Stiffness American Journal of Physiology-heart and Circulatory Physiology · 2018
    4. Direct Vasodilators and Sympatholytic Agents Journal of cardiovascular pharmacology and therapeutics · 2015
    5. Treatment of Severe Hypertension with Minoxidil: Advantages and Limitations The Journal of Clinical Pharmacology · 1979
    6. Minoxidil in Severe Hypertension: Value When Conventional Drugs Have Failed American Heart Journal · 1975
    7. Control Plasma Renin Activity and Changes in Sympathetic Tone as Determinants of Minoxidil-Induced Increase in Plasma Renin Activity Journal of Clinical Investigation · 1975
    8. Differential Effects of Propranolol on Heart Rate and Plasma Renin Activity in Patients Treated with Minoxidil Clinical Pharmacology & Therapeutics · 1974