Increased Levels of Prostaglandin-Like Material in Canine Blood During Arterial Hypotension Produced by Hydralazine, Dihydralazine, and Minoxidil

December 1979 in “ Naunyn-schmiedebergs Archives of Pharmacology ”

Guenther Haeusler, Marcel Gerold

minoxidil hydralazine dihydralazine prostaglandin arterial hypotension vasodilation Rogaine

TLDR These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.

The study found that hydralazine, dihydralazine, and minoxidil increased the levels of prostaglandin-like material in the blood of dogs during arterial hypotension. The increase in prostaglandin-like material was specific to these drugs and not observed with other hypotensive agents. The study suggests that prostaglandins may be responsible for the vasodilation produced by these drugs.

View this study on link.springer.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community So does oral minoxidil age your skin or not

in Minoxidil 44 upvotes 1 year ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community M34 – On finasteride, unsure about starting minoxidil

in Minoxidil 2 upvotes 6 days ago

A 34-year-old male, already on finasteride, is hesitant to continue minoxidil due to side effects like headaches and concerns about facial bloating and skin aging. Another user shares their experience with minoxidil causing facial bloating but hopes for hair growth benefits.

community 20M: Switching Minoxidil 5%/Finasteride 0.1% from Twice to Once Daily?

in Minoxidil 55 upvotes 1 week ago

A 20-year-old is considering switching from applying a Minoxidil 5%/Finasteride 0.1% solution twice daily to once daily due to cost and convenience. It is suggested that applying once a day before sleep should still be effective if done consistently.

community Massive shed coming back on minoxidil

in Minoxidil 8 upvotes 1 week ago

Stopping and restarting minoxidil can cause significant hair shedding. The user is also using finasteride and microneedling to manage hair loss.

community 32M Shedding on Minoxidil & Microneedling After 4 Months - When to Expect Results?

in Minoxidil 78 upvotes 1 week ago

The user has been using finasteride for 8 years and started using minoxidil foam 5% twice daily with micro-needling since May 2025. They experienced significant shedding starting in July and are seeking information on how long the shedding will last and when to expect positive results.

community Switch from topical to oral minoxidil

in Minoxidil 1 upvotes 1 week ago

The conversation discusses switching from topical to oral minoxidil, using oral minoxidil daily and topical minoxidil only on microneedling days. The user also mentions using finasteride and tretinoin but has not seen results after two months.

Related Research

1 / 1 results

research A Comparison of Minoxidil and Hydralazine in Non-Azotemic Hypertensives

26 citations , June 1983 in “Journal of Hypertension”

Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.