Increased Levels of Prostaglandin-Like Material in Canine Blood During Arterial Hypotension Produced by Hydralazine, Dihydralazine, and Minoxidil
December 1979
in “
Naunyn-schmiedebergs Archives of Pharmacology
”
TLDR These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
The study found that hydralazine, dihydralazine, and minoxidil increased the levels of prostaglandin-like material in the blood of dogs during arterial hypotension. The increase in prostaglandin-like material was specific to these drugs and not observed with other hypotensive agents. The study suggests that prostaglandins may be responsible for the vasodilation produced by these drugs.
