Increased Levels of Prostaglandin-Like Material in Canine Blood During Arterial Hypotension Produced by Hydralazine, Dihydralazine, and Minoxidil

December 1979 in “ Naunyn-schmiedebergs Archives of Pharmacology ”

Guenther Haeusler, Marcel Gerold

minoxidil hydralazine dihydralazine prostaglandin arterial hypotension vasodilation Rogaine

TLDR These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.

The study found that hydralazine, dihydralazine, and minoxidil increased the levels of prostaglandin-like material in the blood of dogs during arterial hypotension. The increase in prostaglandin-like material was specific to these drugs and not observed with other hypotensive agents. The study suggests that prostaglandins may be responsible for the vasodilation produced by these drugs.

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research A Comparison of Minoxidil and Hydralazine in Non-Azotemic Hypertensives

26 citations, June 1983 in “Journal of Hypertension”

Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.