Increased Levels of Prostaglandin-Like Material in Canine Blood During Arterial Hypotension Produced by Hydralazine, Dihydralazine, and Minoxidil

December 1979 in “ Naunyn-schmiedebergs Archives of Pharmacology ”

Guenther Haeusler, Marcel Gerold

minoxidil hydralazine dihydralazine prostaglandin arterial hypotension vasodilation Rogaine

TLDR These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.

The study found that hydralazine, dihydralazine, and minoxidil increased the levels of prostaglandin-like material in the blood of dogs during arterial hypotension. The increase in prostaglandin-like material was specific to these drugs and not observed with other hypotensive agents. The study suggests that prostaglandins may be responsible for the vasodilation produced by these drugs.

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in Minoxidil 41 upvotes 1 year ago

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community Is this due to a Minoxidil Shed? Or should I consider switching to Dutasteride

in Minoxidil 3 upvotes 1 week ago

The user is experiencing increased thinning around the crown after starting topical Minoxidil and is considering switching from Finasteride to Dutasteride. Responses suggest the thinning might be a temporary shedding phase due to the new treatment, and it's advised to continue the current regimen and monitor progress.

community Started applying minoxidil to my whole scalp a couple months ago rather than just to my crown— is this sort of shedding normal?

in Minoxidil 27 upvotes 1 week ago

Shedding is common with minoxidil, and it often indicates new hair growth. Users discuss experiences with minoxidil, finasteride, and dutasteride, noting that results can vary and patience is needed.

community If you quit Minoxidil, then your hair sheds, how long before it recovers?

in Minoxidil 76 upvotes 1 week ago

Stopping minoxidil often leads to significant hair shedding, and recovery to baseline can vary, with some users reporting no full recovery. Combining minoxidil with finasteride may help maintain gains, but stopping minoxidil typically results in losing the hair regrowth it provided.

community Minoxidil hairs not growing to full length

in Minoxidil 22 upvotes 2 weeks ago

New hair growth from minoxidil and finasteride is not reaching full length, possibly due to slow growth cycles. Users discuss dosing strategies for oral minoxidil to improve efficacy and minimize side effects, with advice against consuming topical minoxidil orally.

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research A Comparison of Minoxidil and Hydralazine in Non-Azotemic Hypertensives

26 citations, June 1983 in “Journal of Hypertension”

Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.