A Comparison of Minoxidil and Hydralazine in Non-Azotemic Hypertensives

June 1983 in “ Journal of Hypertension ”

Brian F. G. Johnson, Henry R. Black, R. M. Beckner, Bonnie H. Weiner, Fran Angeletti

TLDR Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.

This study compared the effectiveness and side effects of two vasodilators, minoxidil and hydralazine, in non-azotemic hypertensive patients. The study found that minoxidil was more effective in reducing blood pressure, but also caused more adverse effects such as weight gain, oedema, and hypertrichosis (increased body hair growth). Hydralazine produced a greater additional fall in blood pressure 2-4 hours after a dose was ingested, but had diurnal variability. The study suggests that hydralazine should be tried first as a Step 3 agent in non-azotemic hypertensives who are incompletely controlled by a diuretic and beta-blocker combination.

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Related Research

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research The Effects of Minoxidil on Pulmonary and Systemic Hemodynamics in Hypertensive Men

20 citations, February 1977 in “Circulation”

Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.

research Long-Term Treatment of Severe Hypertension with Minoxidil, Propranolol, and Furosemide

55 citations, October 1975 in “Circulation”

Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.