A Comparison of Minoxidil and Hydralazine in Non-Azotemic Hypertensives

June 1983 in “ Journal of Hypertension ”

Brian F. G. Johnson, Henry R. Black, R. M. Beckner, Bonnie H. Weiner, Fran Angeletti

TLDR Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.

This study compared the effectiveness and side effects of two vasodilators, minoxidil and hydralazine, in non-azotemic hypertensive patients. The study found that minoxidil was more effective in reducing blood pressure, but also caused more adverse effects such as weight gain, oedema, and hypertrichosis (increased body hair growth). Hydralazine produced a greater additional fall in blood pressure 2-4 hours after a dose was ingested, but had diurnal variability. The study suggests that hydralazine should be tried first as a Step 3 agent in non-azotemic hypertensives who are incompletely controlled by a diuretic and beta-blocker combination.

View this study on journals.lww.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Minoxidil seems logistically impossible and impractical to use

in Minoxidil 136 upvotes 1 year ago

The post discusses concerns about the practicality of using Minoxidil foam for hair loss, including the frequency of application, preparation, coverage area, and drying time. Responses suggest that missing a dose isn't detrimental, it can be applied once a day, it works on all hair areas, and it doesn't need to be perfectly dry before application.

community 6 week update fellas, 5mg oral minoxidil. Pics are 2nd June – 10th July

in Progress Pictures 2 years ago

, you can find it online with a script This user was discussing their progress with hair loss treatments including 5mg oral Minoxidil and combining 3mg oral Minoxidil with MTF HRT. They also discussed side effects of increased body hair in other parts of the body.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 month ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

community Topical Minoxidil is a pain in the ass for diffuse thinners

in Minoxidil 95 upvotes 1 year ago

Topical minoxidil being a difficult product to apply, with users considering finasteride, RU58841, and oral minoxidil as alternative treatments for diffuse thinning hair. Other advice includes shaving the head in the first 3 months of using minoxidil and finding ways to apply it without saturating the hair.

community switched from topical to oral minoxidil (topical mixed with water) 3 months ago and aside from being much easier i’ve also had much more density overall. My results aren’t even finished yet!

in Progress Pictures 2 years ago

This user discussed using oral minoxidil as a hair loss treatment, and was cautioned against mixing topical minoxidil with water and drinking it due to potential side effects and risks. Other users shared their concerns about the dangers of self-prescribing medications without consulting a doctor.

community 15 Week Update of Oral Consumption of Topical Minoxidil. 3 drops Keeps 5% (3.75mg) 2x per day with comparison.

in Update 2 years ago

CumShotDiva's update on using topical minoxidil orally in an attempt to regrow hair, which has been met with both support and criticism from other users. The conversation includes discussion of possible side effects and the efficacy of this approach.

Related Research

2 / 2 results

research The Effects of Minoxidil on Pulmonary and Systemic Hemodynamics in Hypertensive Men

20 citations, February 1977 in “Circulation”

Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.

research Long-Term Treatment of Severe Hypertension with Minoxidil, Propranolol, and Furosemide

55 citations, October 1975 in “Circulation”

Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.