Long-Term Treatment of Severe Hypertension with Minoxidil, Propranolol, and Furosemide

October 1975 in “ Circulation ”

R. L. Wilburn, A H Blaufuss, C.-M. Bennet

TLDR Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.

The study investigated the long-term treatment of severe hypertension with minoxidil, propranolol, and furosemide. The combination of these drugs was found to be highly effective in controlling severe hypertension for up to 25 months, with no long-term toxic effects of therapy detected. However, severe sodium retention requiring large doses of furosemide to avoid increasing body weight and edema was a frequently observed factor associated with tolerance to the hypotensive effect of arteriolar dilatation.

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Research cited in this study

2 / 2 results

$Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension$

research Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension

180 citations, July 1973 in “The New England Journal of Medicine”

Minoxidil effectively lowers blood pressure with few side effects.

research Minoxidil in Severe Hypertension with Renal Failure

100 citations, March 1973 in “American Journal of Cardiology”

Minoxidil effectively lowers blood pressure without major side effects.

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community Warning: Your Rogaine Foam Might Not Contain Minoxidil

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A user experienced significant hair loss after using Rogaine foam purchased from Amazon, which failed a bleach test for Minoxidil. They discovered that even legitimate Rogaine products might be faulty and advised buying from reputable sources.

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community Hey chooms! Coming in on the 2 year mark soon. Still making progress. (Fin/Min)

in Progress Pictures 607 upvotes 7 months ago

The user reports slow and steady hair regrowth using Finasteride (1.25mg) and topical Minoxidil (Rogaine, 2x/day), along with occasional use of Nizoral. They have stopped dermarolling.

community Do I need to get professional advice?

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A 22-year-old woman is experiencing genetic hair loss and has tried natural remedies like coconut oil and aloe vera without success. She seeks advice on whether to see a dermatologist or use treatments like Minoxidil (Rogaine) despite her parents' skepticism about professional help and chemical treatments.

community Success WITH pics: saw results in 2 months. Variation of BIG 3. I'm 24 years old and been doing it for 8 months now.

in Update 49 upvotes 6 years ago

A user shared their successful hair regrowth routine, which includes finasteride, derma rolling, minoxidil (Rogaine), biotin pills, and vitamin D supplementation, and saw noticeable results in 3 months. They suggest this routine as a variation of the "Big 3" hair loss treatments and have created a website to sell the products they used.

community Topical minoxidil and salicylic acid

in Minoxidil 4 upvotes 4 months ago

The user has been using finasteride for 6 months with decent results and recently added topical minoxidil. They are concerned that salicylic acid in their skincare products might reduce minoxidil's effectiveness.

Related Research

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research A Comparison of Minoxidil and Hydralazine in Non-Azotemic Hypertensives

26 citations, June 1983 in “Journal of Hypertension”

Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.

research Long-Term Treatment of Severe Hypertension with Minoxidil, Propranolol, and Furosemide

55 citations, October 1975 in “Circulation”

Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.