14 citations
,
April 2009 in “Acta Medica Scandinavica” In this study, oral minoxidil combined with other medications improved blood pressure control in patients with severe hypertension but often had to be discontinued due to side effects.
26 citations
,
January 1978 in “Nephron” Minoxidil lowers blood pressure effectively but may cause side effects.
20 citations
,
February 1977 in “Circulation” Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.
34 citations
,
January 1977 in “American Journal of Cardiology”
55 citations
,
October 1975 in “Circulation” Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.
50 citations
,
September 1975 in “American Heart Journal” Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.
57 citations
,
February 1975 in “Journal of Clinical Investigation” This study found that minoxidil increased plasma renin activity in patients with hypertension through both an adrenergic mechanism related to heart rate changes and a secondary mechanism unrelated to propranolol.
25 citations
,
December 1974 in “Clinical Pharmacology & Therapeutics” Propranolol affects heart rate and renin levels in minoxidil-treated patients.
180 citations
,
July 1973 in “The New England Journal of Medicine” In this study, minoxidil effectively reduced blood pressure to near normal levels in patients with malignant or accelerated hypertension resistant to conventional treatments, offering a potential alternative to nephrectomy.
100 citations
,
March 1973 in “American Journal of Cardiology” Minoxidil effectively lowers blood pressure without major side effects.
90 citations
,
May 1972 in “Clinical Pharmacology & Therapeutics” Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.