The Immune System Response in COVID-19 Infection in Polycystic Ovary Syndrome

    May 2021 in “ International Journal Of Medical Science And Clinical Invention ”
    Gülcan Arusoğlu, Kübra Bozay
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    TLDR Women with PCOS may have a higher risk of severe COVID-19 due to hormonal imbalances and vitamin D deficiency.
    The document discusses the potential increased risk of severe COVID-19 infection in women with Polycystic Ovary Syndrome (PCOS), a condition affecting 8-13% of women of reproductive age. The study suggests that women with PCOS, due to hyperandrogenism, may have a 51% higher risk of COVID-19 compared to women without PCOS. The renin-angiotensin system (RAS) shows higher activation in hyperandrogenic women with PCOS, potentially leading to a hyperinflammatory condition that could increase susceptibility to infection. Additionally, 67-85% of women with PCOS have a vitamin D deficiency, which could impair the immune response and increase the risk of systemic infections, including COVID-19. The document recommends that clinicians evaluate the COVID-19 risk profile of women with PCOS and provide practical recommendations for treatment changes and self-isolation.
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