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GlossaryAngiotensin-Converting Enzyme 2 (ACE2)

regulates blood pressure and is a SARS-CoV-2 entry point

Angiotensin-Converting Enzyme 2 (ACE2) is a protein found on the surface of many cell types, including those in the lungs, heart, and kidneys. It plays a crucial role in regulating blood pressure by converting angiotensin II, a molecule that can increase blood pressure, into angiotensin 1-7, which has the opposite effect. ACE2 is also known for being the entry point for the SARS-CoV-2 virus, which causes COVID-19, making it a significant focus of medical research.

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research An Assessment on the Impact of COVID-19 Infection in a Gender-Specific Manner

59 citations , October 2020 in “Stem Cell Reviews and Reports”

Men have higher COVID-19 mortality rates than women due to biological and lifestyle factors.

research COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine

58 citations , December 2020 in “Mayo Clinic Proceedings”

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

research TMPRSS2, Required for SARS-CoV-2 Entry, Is Downregulated in Lung Cells by Enzalutamide, a Prostate Cancer Therapeutic

2 citations , June 2020 in “Research Square (Research Square)”

A prostate cancer drug can lower the levels of a protein that the coronavirus uses to enter lung cells.

research Testosterone in COVID-19: An Adversary Bane or Comrade Boon

23 citations , September 2021 in “Frontiers in Cellular and Infection Microbiology”

Testosterone's effects on COVID-19 are unclear and need more research.

research Skin Tissue: A Place for SARS-CoV-2 to Multiply and Transmit?

1 citations , September 2021 in “Advances in skin & wound care”

SARS-CoV-2 might infect and multiply in skin tissue, possibly aiding in its transmission.

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community Adrogens and Covid-19

in Treatment 8 upvotes 5 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.