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GlossaryAngiotensin-Converting Enzyme 2 (ACE2)

regulates blood pressure and is a SARS-CoV-2 entry point

Angiotensin-Converting Enzyme 2 (ACE2) is a protein found on the surface of many cell types, including those in the lungs, heart, and kidneys. It plays a crucial role in regulating blood pressure by converting angiotensin II, a molecule that can increase blood pressure, into angiotensin 1-7, which has the opposite effect. ACE2 is also known for being the entry point for the SARS-CoV-2 virus, which causes COVID-19, making it a significant focus of medical research.

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research ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-CoV-2 in Cancer Patients

38 citations , January 2020 in “Cell Transplantation”

Targeting ACE2 and TMPRSS2 may help prevent or treat COVID-19 in cancer patients.

research Role of ACE2 Polymorphism in COVID-19: Impact of Age

6 citations , May 2021 in “Clinical Chemistry and Laboratory Medicine”

Different ACE2 gene versions may affect COVID-19 impact based on age and suggest some hair loss drugs could be potential treatments.

research The Impact of Angiotensin-Converting Enzyme 2 Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review

52 citations , August 2021 in “Microorganisms”

Higher ACE2 levels in certain tissues may worsen COVID-19 in people with other health issues, especially older adults.

research Analyzing the Role of ACE2, AR, MX1, and TMPRSS2 Genetic Markers for COVID-19 Severity

9 citations , June 2023 in “Human Genomics”

MX1 and AR genes are linked to milder COVID-19, while TMPRSS2 increases severe risk, especially in women.

research Inhibition of SARS-CoV-2 Entry Through the ACE2/TMPRSS2 Pathway: A Promising Approach for Uncovering Early COVID-19 Drug Therapies

77 citations , July 2020 in “European Journal of Clinical Pharmacology”

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

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community Adrogens and Covid-19

in Treatment 7 upvotes 5 years ago

The possible increased risk of severe Covid-19 cases in men due to higher androgen levels, and how taking medications such as finasteride, dutasteride, spironolactone, enzalutamide, or canabidiol might help mitigate the severity of the disease.