From Bedside to Bench: Regulation of Host Factors in SARS-CoV-2 Infection
April 2021
in “
Experimental and Molecular Medicine
”
TLDR The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.
The document reviews the role of host factors, particularly ACE2 and TMPRSS2, in the severity of COVID-19. It discusses how these factors are involved in viral entry and their expression in different tissues, which may correlate with the variability in symptoms and outcomes of the disease. The review also examines genetic variants and their association with severe COVID-19, noting that while some variants at the 3p21.31 locus and in the IFN pathway and IL6R are linked to disease severity, variants in ACE2 and TMPRSS2 are not convincingly associated with it. Additionally, the ABO blood group's influence on COVID-19 risk is mentioned. The importance of understanding the regulation of these host factors and the potential genetic components of disease susceptibility and severity is emphasized, with the aim of improving risk stratification and therapeutic interventions.
