Genetic Variants and Protective Immunity Against SARS-CoV-2

    December 2022 in “ Genes ”
    Ali A. Rabaan, Abbas Al Mutair, Mohammed Aljeldah, Basim R. Al Shammari, Tarek Sulaiman, Abeer N. Alshukairi, Mubarak Alfaresi, Jumana M. Al-Jishi, Neda A. Al Bati, Maha Al-Mozaini, Ali Al Bshabshe, Jenan Al‐Matouq, Abdulmonem A. Abuzaid, Amal H. Alfaraj, Wasl Al-Adsani, Mohammed Alabdullah, Sara Alwarthan, Fatimah Alsalman, Ameen S. S. Alwashmi, Saad Alhumaid
    TLDR Genetic differences affect how people respond to COVID-19.
    This review explores the role of host genetic factors in susceptibility and resistance to COVID-19, highlighting findings from Genome-Wide Association Studies (GWAS) across different populations. It examines how genetic variations influence the immune response and impact various stages of SARS-CoV-2 pathogenesis, including viral entry, pathophysiological changes, and immune reactions. The study emphasizes the importance of understanding these genetic components to better comprehend COVID-19 susceptibility and pathogenesis, especially in the context of co-morbidities like hypertension, diabetes, and immunosuppression.
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