Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti-Androgens a Potential Treatment for COVID-19?

April 2020 in “ Journal of Cosmetic Dermatology ”

John D. McCoy, Carlos Gustavo Wambier, Sergio Vano-Galvan, Jerry Shapiro, Rodney Sinclair, Paulo Müller Ramos, Kenneth Washenik, Murilo Ferreira de Andrade, Sabina Herrera, Andy Goren

androgen receptor androgenetic alopecia anti-androgens androgen modulating drugs androgens SARS-CoV-2 male pattern baldness anti-androgen drugs

TLDR Genetic differences may affect COVID-19 deaths; anti-androgens could be potential treatment.

The article suggests that genetic variations in the androgen receptor may be a contributing factor to the racial disparities in COVID-19 deaths. The authors propose that androgens may be implicated in COVID-19 disease severity and that special attention may need to be given to African Americans infected with the virus. The article suggests that anti-androgens or androgen modulating drugs may be beneficial in treating COVID-19, particularly if androgen sensitivity can be confirmed as a predisposition to SARS-Cov-2 disease severity.

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