research Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review
This study found that anti-androgens may reduce OCD symptoms, but the evidence is of low quality and further large, randomized trials are needed.
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5 / 1000+ resultsresearch Antiandrogen Drugs Lower Serum Prostate-Specific Antigen (PSA) Levels in Hirsute Subjects: Evidence That Serum PSA Is a Marker of Androgen Action in Women1
This study found that serum PSA levels are higher in hirsute women and can be significantly reduced by antiandrogen treatment, suggesting PSA as a marker of androgen action in females.
research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.
research Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride
This study provided the crystal structure of the human steroid 5α-reductase 2 enzyme and identified key molecular mechanisms for testosterone reduction and finasteride inhibition, aiding in understanding disease-causing mutations and potentially facilitating new drug development.
research Racial variations in COVID‐19 deaths may be due to androgen receptor genetic variants associated with prostate cancer and androgenetic alopecia. Are anti‐androgens a potential treatment for COVID‐19?
This article discusses the potential link between genetic variants associated with androgen receptor activity and racial variations in COVID-19 mortality, suggesting a possible role for anti-androgens in treatment, but reports no new clinical findings.
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5 / 1000+ resultscommunity Anti-Androgens causing hairline to recede?
Anti-androgens like Finasteride, Dutasteride, Metformin, and Topical Spironolactone cause hairline recession and increased cholesterol levels. The hairline recovers after stopping the drugs.
community 22M, dutasteride + spironolactone miracle, I was losing 400-500 hairs everyday, after starting the drugs I completely stopped shedding and experienced crazy regrowth in just 3-4 months
A 22-year-old male experienced significant hair regrowth and stopped shedding after using dutasteride and spironolactone for 3-4 months. Spironolactone is discussed as an antiandrogen, typically used for women or transitioning individuals, and not commonly recommended for men due to potential side effects.
community Anti-androgen use causing testicular pain?
Switching from topical finasteride to oral Dutasteride and using Fluridil caused persistent testicular discomfort. The discomfort did not subside after stopping Fluridil, raising concerns about Dutasteride's role.
community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?
RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.
community Cheap topical anti-androgens recommendations?
The conversation is about finding affordable topical anti-androgens for hair loss. The user is currently using finasteride, dutasteride, and oral minoxidil, and is advised that additional topical treatments may not be necessary.
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7 / 14 results- Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide (KX-826) is an unapproved, investigational topical antiandrogen whose safety data come from short-term sponsor announcements, not peer-reviewed studies. No study has compared it with finasteride, so there is no evidence that it is safer.
- Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in men and women but is not approved for hair loss anywhere. Its sponsor reports one failed (2023) and one successful (2026) Phase III in men, none of it peer-reviewed; long-term safety is unknown, and anti-androgens are not considered appropriate in pregnancy.
- What is pyrilutamide, and how does it help with androgenic alopecia or hair loss caused by DHT? Pyrilutamide (KX-826) is an investigational topical antiandrogen designed to block DHT at the androgen receptor in the scalp. Its sponsor reported that a 2023 China Phase III of a 0.5% tincture did not beat placebo and that a 2026 Phase III stage of a 1.0% tincture did; none of the data are peer-reviewed and it is not approved as a medicine anywhere.
- What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is an investigational topical androgen-receptor degrader. One 12-week Phase II trial in 180 Chinese men found two of four regimens beat placebo on hair count; it is not approved or available.
- What does Fluridil do on the scalp, and how does it block the DHT hormone? Fluridil is a topical anti-androgen sold in some European countries. One small 2002 trial led by its developer reported more hairs in the growth phase; it is not FDA-approved and the evidence is limited.
learn Spironolactone
A prescription blood-pressure and diuretic drug with anti-androgen effects, used off-label mainly by women for pattern hair loss.
learn Fluridil
A topical antiandrogen sold as a cosmetic (Eucapil), tested in one small 2002 trial in men.
learn Bicalutamide
A nonsteroidal antiandrogen licensed for prostate cancer; sometimes prescribed off-label for female pattern hair loss, with liver monitoring. Not for use in pregnancy.
learn Pyrilutamide
Pyrilutamide (KX-826) is an investigational topical antiandrogen. It is not approved anywhere, and its trial results, including a failed 2023 Phase III and a positive 2026 one, are sponsor-reported and not peer-reviewed.
learn Dutasteride
A stronger DHT blocker than finasteride, approved for hair loss only in South Korea and Japan and off-label elsewhere, with the same class of side effects and a much longer washout.
