RU58841
also ru, PSK-3841, HMR-3841
RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) which was initially developed in the 1980s by Roussel Uclaf, the French pharmaceutical company from which it received its name. It was formerly under investigation by ProStrakan for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth. The compound is similar in structure to the NSAA RU-58642 but contains a different side-chain. These compounds are similar in chemical structure to nilutamide, which is related to flutamide, bicalutamide, and enzalutamide, all of which are NSAAs similarly. RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydantoin.
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Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.
Research 10
- A multi-centre, double-blind, randomised, vehicle-controlled study for a quantitative estimation of hair re-growth in male subjects with androgenetic alopecia treated over 6 month with two ethanolic PSK 3841 solutions (2.5% and 5%)
- RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism
- Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque
- RU 58841-myristate–prodrug development for topical treatment of acne and androgenetic alopecia.
- Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque<sup>1</sup>
- A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice
- CLINICAL UPDATES IN HAIR
- Alternative synthesis of the anti-baldness compound RU58841
- Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque.
- Significance of RU58841 as a therapeutic agent effecting androgen receptor molecular interactions in human hair follicles.
Community 10
- Ru58841 + minoxidil + nizoral + dermastamp
- RU58841 - Side Effects - Day 4: Chest Pain & Tightness, Bloodshot Eyes and some sort of inflammation/irritation on my throat.
- My current hair loss regimen - 2,5mg dut,oral min 2,5mg, topical min,ru58841
- RU58481, are side effects exegerated?
- Consenus on Kx-826/pyrilutamide vs ru58841
- Seeking Advice on Using RU58841 2% After Finasteride Side Effects
- Is RU58841 making a comeback? Is it worth it?
- Doubtful of RU58441's negative effects
- KX-826 and RU58841: do topical anti-androgens work?
- New human study (Aug 2026) directly tested whether RU58841 stays local - it doesn't