Percutaneous Absorption of a New Antiandrogen Included in Liposomes or in Solution

    December 1995 in “ International Journal of Pharmaceutics ”
    Ethan Bernard, Jean-Luc Dubois, J Wepierre
    Image of study
    TLDR Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.
    In 1995, a study was conducted to compare the absorption and distribution of a new antiandrogen, RU 58841, when included in liposomes or in solution. The study found that liposomes significantly reduced the percutaneous absorption of RU 58841 compared to the solution, but resulted in slower permeation of the drug and a longer duration in the skin. Liposomes also led to an accumulation of the drug in the sebaceous structures. The study concluded that liposomes could be more favorable for topical application as they reduce absorption, increase retention of the drug in the skin, and target the sebaceous structures.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 784 results

      community Why isn't fluridil more widely used and known about?

      in Treatment  8 upvotes 4 years ago
      Fluridil, an antiandrogen that is not widely used or known about due to its expense and lack of availability in the US. It is suggested as a potential alternative for people who don't want to lower their DHT through treatments such as Minoxidil, Finasteride, Nizoral shampoo, and Dermarolling.

      community I have tried many treatments but it's getting worse. 23M.

      in Treatment  85 upvotes 3 weeks ago
      A 23-year-old male experiencing worsening hair loss has tried topical Minoxidil, Finasteride, Progesterone, Hydrocortisone butyrate, and Ketoconazole. He is considering switching to oral Finasteride due to concerns about side effects and lack of improvement.

      community Has anyone used the new liposomal topical fin from Hasson and Wong?

       6 upvotes 8 years ago
      The conversation discusses a new liposomal topical finasteride from Hasson and Wong, available in Canada and Italy, soon in the US, costing $40/month. It claims to reduce scalp DHT by 50% without affecting serum DHT, potentially benefiting those who can't tolerate oral finasteride or RU58841.

      community So we’re just ok with taking a research chemical now?

      in Treatment  178 upvotes 3 years ago
      The conversation discusses the use of RU58841, a non-FDA approved research chemical for hair loss, with mixed opinions on its safety and effectiveness. Some users are willing to try it as a last resort after other treatments like Minoxidil and Finasteride failed, while others express concerns about potential long-term side effects and lack of official research.

    Similar Research

    5 / 1000+ results