Transfollicular Drug Delivery: Is It a Reality?
December 2005
in “
International journal of pharmaceutics
”
hair follicles sebaceous glands percutaneous drug delivery pilosebaceous units acne alopecia systemic drug delivery formulations targeting follicles transfollicular drug delivery skin drug delivery hair units hair loss body-wide drug delivery follicle-targeting formulations through-hair drug delivery
TLDR Hair follicles may soon be used more for targeted and systemic drug delivery.
In the document from December 2005, hair follicles and sebaceous glands were increasingly recognized as important for percutaneous drug delivery. The pilosebaceous units were being considered for localized treatments, especially for conditions like acne and alopecia, and also for systemic drug delivery. The paper reviewed the anatomy and physiology of these units, the design and effectiveness of formulations targeting the follicles, and the development of quantitative models. It highlighted that novel developments were expected to significantly enhance the understanding of transfollicular drug delivery in the near future.
