Dermal Delivery of Topically Applied Oligonucleotides via Follicular Transport in Mouse Skin

April 2005 in “ Journal of Investigative Dermatology ”

Sujatha Dokka, Scott Cooper, Susan Kelly, Gregory E. Hardee, James G. Karras

oligonucleotides 2'-O-methoxyethyl-modified oligonucleotides follicular transport hair follicles topical oligonucleotide therapy epidermis dermis topical therapy skin layers

TLDR Topical oligonucleotide therapy targets hair follicles effectively.

The study demonstrated that antisense oligonucleotides (ASO) could be effectively delivered into the dermis of BALB/c mice via hair follicles when formulated in a lipophilic cream, but not with saline formulations. The cream's lipophilicity facilitated the ASO's entry through the hair follicles, suggesting that the right hydrophilic/hydrophobic balance in the formulation was crucial for effective dermal delivery. This method showed potential for localized drug delivery to hair follicles and treating skin disorders, though further research was needed to fully understand the enhanced delivery mechanism.

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