Evaluation of the Hairless Rat as a Model for In Vivo Percutaneous Absorption
January 1997
in “
Journal of Pharmaceutical Sciences
”
New to Mannitol? There is a guide in the encyclopedia. Read the guide → Studysummary This study observed that hairless rat skin was more permeable to mannitol and progesterone than hairy rat skin, indicating that follicular structures significantly impact percutaneous absorption.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study evaluated the hairless rat as a model for in vivo percutaneous absorption by comparing it to the hairy rat. It was found that hairless rat skin was a "leakier" barrier for polar compounds like mannitol, leading to higher absorption rates than in hairy rats. Progesterone absorption was also significantly higher in hairless rats. The study suggested that the structural differences in hairless rats, such as patulous cysts and enlarged sebaceous glands, might enhance absorption pathways. These findings highlighted the importance of follicular structures in passive percutaneous absorption and demonstrated significant differences in absorption based on the animal model used.
