RU 58841-Myristate Prodrug Development for Topical Treatment of Acne and Androgenetic Alopecia

    January 2005 in “ PubMed
    U. Münster, C Nakamura, A. Haberland, K. Jores, W. Mehnert, S. Rummel, Martin Schaller, Hans Christian Korting, Zouboulis ChC, Ulrike Blume-Peytavi, Monika Schäfer-Korting
    TLDR RUM-loaded SLN shows promise for treating acne and hair loss topically.
    The study focused on developing RU 58841-myristate (RUM) as a prodrug for topical treatment of acne and androgenetic alopecia. RUM, which has minimal affinity for the androgen receptor, was rapidly converted to the potent antiandrogen RU 58841 by various human skin cells. To enhance targeting to hair follicles, RUM was loaded onto solid lipid nanoparticles (SLN). These SLN were physically stable and showed negligible permeation through reconstructed epidermis and porcine skin, suggesting a localized effect. Fluorescence and transmission electron microscopy confirmed the targeting of SLN to hair follicles. The findings supported the potential of RUM-loaded SLN for topical antiandrogen therapy.
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      community RU 58841 or do I go for Nizoral shampoo instead? Have curly hair

      in Ketoconazole  1 upvotes 1 month ago
      The user is considering whether to add RU58841 or Nizoral shampoo to their current hair loss treatment of finasteride and minoxidil, noting budget constraints and concerns about hair dryness. They are unsure if RU58841 is worth adding or if they should use both treatments to see the effects.

      community RU-58841 without finassteride?

      in Treatment  6 upvotes 3 months ago
      RU58841 is used without finasteride by some due to side effects, with mixed results. Users report combining RU58841 with minoxidil and adjusting finasteride doses to manage hair loss.

      community Ru-58841 vs KX-826/pyrilutamide while on steroids

      in Finasteride/Dutasteride  6 upvotes 11 months ago
      The user increased their steroid dosage and noticed hair shedding, so they adjusted their regimen by reducing steroid doses and adding oral dutasteride. They are also experimenting with combining RU-58841 and KX-826/pyrilutamide in minoxidil to address hair loss.

      community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

      in Treatment  20 upvotes 1 year ago
      Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

      community Ru-58841 or KX-826 (Pyrilutamide)?

      in Treatment  12 upvotes 2 years ago
      Exploring potential treatments for hair loss, with the focus being on comparing RU58841 and Pyrilutamide. Finasteride, Dutasteride, oral Minoxidil, microneedling, topical Minoxidil, Biotin, Zinc, Vitamin D and Nizoral are also discussed as part of a treatment stack.

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