TLDR RUM-loaded SLN shows promise for treating acne and hair loss topically.
The study focused on developing RU 58841-myristate (RUM) as a prodrug for topical treatment of acne and androgenetic alopecia. RUM, which has minimal affinity for the androgen receptor, was rapidly converted to the potent antiandrogen RU 58841 by various human skin cells. To enhance targeting to hair follicles, RUM was loaded onto solid lipid nanoparticles (SLN). These SLN were physically stable and showed negligible permeation through reconstructed epidermis and porcine skin, suggesting a localized effect. Fluorescence and transmission electron microscopy confirmed the targeting of SLN to hair follicles. The findings supported the potential of RUM-loaded SLN for topical antiandrogen therapy.
30 citations,
April 2018 in “Experimental Dermatology” The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.
256 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
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June 2013 in “British Journal of Dermatology” Intense pulsed light treatment mainly damages pigmented hair parts but spares stem cells, allowing hair to regrow.
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June 2013 in “PLOS ONE” Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.
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January 2005 in “PubMed” RUM-loaded SLN shows promise for treating acne and hair loss topically.
34 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Human hair growth is influenced by androgen hormones, and red deer mane follicles have similar hormone receptors.
