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GlossaryReconstructed Human Epidermis

laboratory-grown model of human skin for research and testing

Reconstructed Human Epidermis (RHE) is a laboratory-grown model of human skin created from cultured human skin cells. It mimics the structure and function of the outermost layer of the skin, making it a valuable tool for testing cosmetics, pharmaceuticals, and studying skin biology without the need for animal testing.

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Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators

research Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators

3 citations , December 2000 in “International Journal of Cosmetic Science”

The study created a new method to test drugs that affect hormone processing in skin.

research Epidermis Reconstructed from the Outer Root Sheath of Human Hair Follicle: Effect of Retinoic Acid

18 citations , June 1993 in “Archives of Dermatological Research”

Human hair follicles can be used to create skin-like tissue for wound healing and drug testing.

research Architecture of Reconstructed Epidermis on Collagen Lattices Varies According to the Method Used: A Comparative Study

9 citations , January 1990 in “Skin Pharmacology and Physiology”

The method and source of keratinocytes affect the structure of reconstructed skin.

research Establishment of a New Three-Dimensional Human Epidermal Model Reconstructed from Plucked Hair Follicle-Derived Keratinocytes

12 citations , May 2016 in “Experimental Dermatology”

A new skin model from hair follicles is a safer, simpler alternative for skin tests.

research RU 58841-Myristate Prodrug Development for Topical Treatment of Acne and Androgenetic Alopecia

26 citations , January 2005 in “PubMed”

RUM-loaded SLN shows promise for treating acne and hair loss topically.

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community Before hair transplant and after 19 months update, no finasteride no minoxidil only some vitamins

in Update 293 upvotes 4 years ago

A user shared their positive hair transplant results after 19 months without using finasteride or minoxidil, only vitamins. Some responses suggest concern over future hair loss without prevention treatments, while others congratulate or express jealousy.

community Not much progress; don't know if there's any at all. Is it still worth taking?

in Is this regrowth? 6 upvotes 5 months ago

The user has been using oral Minoxidil and Finasteride for hair loss, with some noticing slight regrowth, particularly baby hairs, but overall progress is unclear. Suggestions include continuing the current treatment, considering a hair transplant, or trying additional therapies like topical treatments or laser therapy.

community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

in Finasteride/Dutasteride 52 upvotes 2 years ago

Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.

community Bald to back 12 month update. Thanks everyone for the 34K views on previous post.

in Is this regrowth? 177 upvotes 6 months ago

A user shared a 12-month update on their hair transplant, which involved 5700 DHI grafts and cost £4500 at Cosmedica. They also dyed their hair and beard, and users praised the impressive results, suggesting finasteride or dutasteride to prevent further hair loss.

community M24 Finasteride (4M) minoxidil (2Y)

in Progress Pictures 57 upvotes 2 years ago

FalseHour6541's two-year experience with Minoxidil and Finasteride, resulting in good density on their crown; other users suggested a hair transplant to help reduce the receding hairline.

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