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GlossaryReconstructed Human Epidermis

laboratory-grown model of human skin for research and testing

Reconstructed Human Epidermis (RHE) is a laboratory-grown model of human skin created from cultured human skin cells. It mimics the structure and function of the outermost layer of the skin, making it a valuable tool for testing cosmetics, pharmaceuticals, and studying skin biology without the need for animal testing.

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Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators

research Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators

3 citations, December 2000 in “International Journal of Cosmetic Science”

The study created a new method to test drugs that affect hormone processing in skin.

research RU 58841-Myristate Prodrug Development for Topical Treatment of Acne and Androgenetic Alopecia

26 citations, January 2005 in “PubMed”

RUM-loaded SLN shows promise for treating acne and hair loss topically.

research Allergens of Permanent Hair Dyes Induce Epidermal Damage, Skin Barrier Loss, and IL-1 Alpha Increase in Epidermal In Vitro Model

12 citations, December 2017 in “Food and chemical toxicology”

Permanent hair dye mixtures can irritate and damage the skin.

research Design of an In Vitro Skin 3D Model Mimicking a Disruption of the Barrier Function

September 2017 in “Journal of Investigative Dermatology”

Activating the hexosamine pathway can improve skin health and increase hair follicle stem cells.

research The Role of EAAT4 in Epidermal Differentiation and Calcium Homeostasis During Aging

December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

EAAT4 decreases with age, harming skin function and calcium balance.

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community Before hair transplant and after 19 months update, no finasteride no minoxidil only some vitamins

in Update 294 upvotes 3 years ago

A user shared their positive hair transplant results after 19 months without using finasteride or minoxidil, only vitamins. Some responses suggest concern over future hair loss without prevention treatments, while others congratulate or express jealousy.

community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

in Finasteride/Dutasteride 52 upvotes 1 year ago

Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.

community M24 Finasteride (4M) minoxidil (2Y)

in Progress Pictures 57 upvotes 1 year ago

FalseHour6541's two-year experience with Minoxidil and Finasteride, resulting in good density on their crown; other users suggested a hair transplant to help reduce the receding hairline.

community Redensyl (The Ordinary Serum)

in Treatment 20 upvotes 4 years ago

Redensyl, a hair loss treatment that has been claimed to be 80% more effective than minoxidil, but users have not experienced any results from using it.

community Discussion on Finasteride and life.

in Chat 164 upvotes 2 months ago

Finasteride can aid hair regrowth but may cause side effects like depression and sexual dysfunction. Users discuss experiences with finasteride, minoxidil, and RU58841, highlighting varied responses and the importance of informed treatment choices.

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