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    Glossary Reconstructed Human Epidermis

    laboratory-grown model of human skin for research and testing

    Reconstructed Human Epidermis (RHE) is a laboratory-grown model of human skin created from cultured human skin cells. It mimics the structure and function of the outermost layer of the skin, making it a valuable tool for testing cosmetics, pharmaceuticals, and studying skin biology without the need for animal testing.

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    1. Expression of type 1 5α-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic®): a new model for screening skin-targeted androgen modulators International Journal of Cosmetic Science · 2000 · 3 citations
    2. 692 Study of the impact of SKPs’ secreted factors and of a botanical extract derived from jasmine on keratinocytes growth and reconstructed human epidermis thickness Journal of Investigative Dermatology · 2016
    3. Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid Archives of Dermatological Research · 1993 · 18 citations
    4. 890 Development of pigmented reconstructed human epidermis model containing human melanoblasts from keratinocyte culture Journal of Investigative Dermatology · 2019
    5. Epidermis reconstructed from the outer root sheath of human hair follicle on de-epidermized dermis. Effect of retinoic acid Journal of Dermatological Science · 1993
    6. Establishment of a new three‐dimensional human epidermal model reconstructed from plucked hair follicle‐derived keratinocytes Experimental Dermatology · 2016 · 12 citations
    7. 1331 Glutathione (GSH) distribution by quantitative MALDI imaging in reconstructed human skin upon activation of GSH biosynthesis by Nrf2 pathway activator Journal of Investigative Dermatology · 2018
    8. LB788 Development of a novel three-dimensional human epidermal model from plucked hair follicle-derived keratinocytes 2016
    9. Comparison of Activities Dependent on Glutathione S-Transferase and Cytochrome P-450 IA1 in Cultured Keratinocytes and Reconstructed Epidermal Models Skin Pharmacology and Physiology · 2002 · 42 citations
    10. Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model Food and chemical toxicology · 2017 · 12 citations
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