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research RU 58841-myristate–prodrug development for topical treatment of acne and androgenetic alopecia.

26 citations , January 2005 in “PubMed”

This study reports that RU 58841-myristate, a new antiandrogen prodrug formulated with solid lipid nanoparticles, shows potential for targeting hair follicles in preclinical laboratory settings.

research Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque.

1 citations , January 1997 in “Journal of Investigative Dermatology”

In this study using a macaque model, RU58841 at a 5% concentration significantly increased hair density, thickness, and length in the frontal bald scalp over six months.

research Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance

4 citations , October 2007 in “Dermatologic Clinics”

This review discusses the roles of glucocorticoid and sex hormone receptors in the skin and their clinical importance, but reports no new research findings.

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque¹

33 citations , January 1997 in “Endocrinology”

Testosterone was found to inhibit hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps were present, and this effect was reversed by the antiandrogen RU 58841.

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

19 citations , January 1997 in “Endocrinology”

This study observed that testosterone inhibits hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps are present, with antiandrogen RU 58841 reversing this effect.

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Community Join

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community RU-58841 appears to not be soluble in common Minoxidil solutions

7 upvotes 1 year ago

RU-58841 does not dissolve well in common Minoxidil solutions due to water content, requiring a 70/30 ethanol/propylene glycol mix. Users report using separate solutions for RU-58841 and finasteride/Minoxidil for better results.

community RU 58841 or do I go for Nizoral shampoo instead? Have curly hair

in Ketoconazole 1 upvotes 1 year ago

The user is considering whether to add RU58841 or Nizoral shampoo to their current hair loss treatment of finasteride and minoxidil, noting budget constraints and concerns about hair dryness. They are unsure if RU58841 is worth adding or if they should use both treatments to see the effects.

community RU-58841 without finassteride?

in Treatment 6 upvotes 1 year ago

RU58841 is used without finasteride by some due to side effects, with mixed results. Users report combining RU58841 with minoxidil and adjusting finasteride doses to manage hair loss.

community Ru-58841 vs KX-826/pyrilutamide while on steroids

4 upvotes 1 year ago

The user increased their steroid dosage and noticed hair shedding, so they adjusted their regimen by reducing steroid doses and adding oral dutasteride. They are also experimenting with combining RU-58841 and KX-826/pyrilutamide in minoxidil to address hair loss.

community RU-58441 Janoshik test result of Made-In-China Supplier

29 upvotes 10 months ago

A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

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Learn

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learn RU58841

Experimental topical anti-androgen sold as a research chemical

Is RU58841 magic or a scam? Does it really stop baldness? RU58841 is an unapproved research chemical: the published evidence is animal and lab work from the 1990s, there has never been a controlled human trial for hair loss, and nothing sold online is quality-controlled — so its effect and its long-term safety in people are both unknown.
How does RU58841 compare with minoxidil and finasteride? Minoxidil and finasteride (men only) are approved medicines with labels that list their side effects. RU58841 is an unapproved research chemical with no published human trial for hair loss, and a small 2026 study found it reaches the blood after scalp use.
Will I lose my hair if I stop using RU58841? (Spoiler: I might.) There is no published human trial of stopping RU58841; community members commonly report shedding within weeks to months, and androgen biology suggests miniaturization would resume once the topical anti-androgen is withdrawn.
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Clinics

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Hair Transplant
Volosy.ru, Meditsinskiy TsentrSaint Petersburg · RU

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