Characterization of Hair Follicle Development in Engineered Skin Substitutes

    June 2013 in “ PLOS ONE ”
    Penkanok Sriwiriyanont, Kaari A. Lynch, Kevin L. McFarland … Steven T. Boyce
    Studysummary This study demonstrated that engineered skin substitutes using human keratinocytes and murine dermal papilla cells can develop pigmented hairs without sebaceous glands, suggesting separate pathways for hair development and eruption.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.plos.org →
    Discuss this study in the Community →

    Research cited in this study 11

    1. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    2. TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function Journal of Investigative Dermatology · 2011
    3. TCF/Lef1 Activity Controls Establishment of Diverse Stem and Progenitor Cell Compartments in Mouse Epidermis The EMBO Journal · 2011
    4. Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin Journal of Investigative Dermatology · 2011
    5. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    6. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    7. Interleukin 6 Induces the Hair Follicle Growth Phase (Anagen) Journal of Dermatological Science · 2006
    8. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    9. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    10. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    11. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000

    Related research 8

    1. An Extract of Leontopodium Alpinum Prolongs Anagen Phase in Human Hair Follicles Ex Vivo Journal of Investigative Dermatology · 2021
    2. Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland Experimental Dermatology · 2018
    3. Tissue Engineered Human Hair Follicles from Genetically, Environmentally, and Extrinsically Reprogrammed Dermal Papilla Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    4. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    5. Characterization of Hair Follicle Development in Engineered Skin Substitutes PLOS ONE · 2013
    6. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    7. Hair Follicle Units Improving the Construction of Tissue Engineered Skin In Vitro Journal of Tissue Engineering and Reconstructive Surgery · 2013
    8. Roxithromycin Antagonizes Catagen Induction in Murine and Human Hair Follicles: Implication of Topical Roxithromycin as Hair Restoration Reagent Archives of Dermatological Research · 2008