Studysummary This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 29

    1. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    2. The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity Nature · 2011
    3. Sebaceous Gland Loss and Inflammation in Scarring Alopecia: A Potential Role in Pathogenesis Journal of The American Academy of Dermatology · 2011
    4. TCF/Lef1 Activity Controls Establishment of Diverse Stem and Progenitor Cell Compartments in Mouse Epidermis The EMBO Journal · 2011
    5. Epigen Transgenic Mice Develop Enlarged Sebaceous Glands Journal of Investigative Dermatology · 2009
    6. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    7. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009
    8. Obesity Resistance of the Stearoyl-CoA Desaturase-Deficient (Scd1 -/-) Mouse Results from Disruption of the Epidermal Lipid Barrier and Adaptive Thermoregulation Biological Chemistry · 2007
    9. The Role of Fibroblast Growth Factor Receptor 2b in Skin Homeostasis and Cancer Development The EMBO Journal · 2007
    10. Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes In Vitro Hormone and metabolic research · 2007
    11. Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006
    12. Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity Cancer Research · 2006
    13. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    14. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    15. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004
    16. Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation European journal of cell biology · 2004
    17. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    18. Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles Journal of Investigative Dermatology · 2002
    19. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    20. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    21. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    22. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    23. Abnormal Differentiation of Epidermis in Transgenic Mice Constitutively Expressing Cyclooxygenase-2 in Skin Proceedings of the National Academy of Sciences · 2001
    24. Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    25. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001
    26. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000
    27. Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias Archives of dermatology · 1999
    28. Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone Skin Pharmacology and Physiology · 1994
    29. Male Pattern Alopecia: A Histopathologic and Histochemical Study Journal of Cutaneous Pathology · 1975