Stem Cells in the Skin

    October 2016
    Hongwei Wang, Zhonglan Su, Shiyu Song, Ting Su, Mengyuan Niu, Yaqi Sun, Hui Xu
    Image of study
    TLDR Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
    The document from October 18, 2016, provides a comprehensive overview of the role of stem cells in the skin's structure, function, and regeneration. It explains the different types of skin stem cells, including hair follicle stem cells (HFSCs), interfollicular epidermal stem cells (IFESCs), sebaceous gland stem cells, melanocyte stem cells (McSCs), and adipose-derived stem cells (ADSCs), and their roles in maintaining tissue homeostasis and repair. The document details the methods for identifying and isolating these cells, the importance of their niches, and the signaling pathways that control their differentiation, particularly focusing on the Wnt signaling pathway. It also discusses the impact of aging on stem cell function, the role of stem cells in skin cancer, and their potential in medical applications like tissue engineering and skin repair. Advances in skin tissue engineering are highlighted, including successful outcomes in healing chronic leg ulcers and the potential of 3D bioprinting, as well as the promise of MSCs and ADSCs in enhancing wound healing and reducing scarring. The document concludes with the importance of understanding stem cell functions for developing effective therapies for skin disorders and the anticipation of more clinical trials to assess long-term effects of skin stem cell therapies.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 1000+ results

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 9 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community Fun thought experiment about halting hair loss permamently

      in Research/Science  58 upvotes 6 months ago
      A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

      community Is there any new drug that looks promising ?

      in Research/Science  25 upvotes 8 months ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

    Similar Research

    5 / 1000+ results