Epidermal Stem Cells in Orthopedic Regenerative Medicine

The document reviewed the potential of epidermal stem cells (ESCs) in orthopedic regenerative medicine, emphasizing their ability to differentiate into various cell types crucial for tissue repair, such as osteoblasts, chondrocytes, neurons, and Schwann cells. It highlighted the advantages of ESCs, including their accessibility, high proliferative capacity, and immune-privileged properties. The study discussed methodologies for isolating and expanding ESCs and their applications in preclinical models, such as wound healing, nerve and spinal cord injury repair, and bone remodeling. Despite promising results, challenges like biological safety, long culture times, and the need for further research to fully understand their therapeutic potential and optimize clinical use were noted.