TLDR Notch signalling helps skin cells differentiate and prevents tumors.
The document discussed the critical role of Notch signaling in regulating epidermal differentiation, cancer, and cell adhesion. Notch signaling promoted differentiation in hair follicles, sebaceous glands, and interfollicular epidermal lineages, and acted as a tumor suppressor in the skin. Genetic studies showed its necessity for postnatal maintenance of hair follicles and sebaceous glands, and its regulation of terminal differentiation in the interfollicular epidermis. Notch1 inhibition led to squamous cell carcinomas and increased tumor sensitivity to activated Ras. The pathway also influenced cell fate decisions, interacted with other pathways like Wnt and Vitamin A, and modulated cell adhesion by affecting integrin expression and the activity of ROCK2 and MRCKα. The study emphasized the complexity of Notch signaling, its non-cell autonomous effects, and the distinct cellular responses elicited by different Notch ligands.
153 citations,
October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
508 citations,
February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
62 citations,
January 2000 in “Developmental dynamics” Notch-related genes play a key role in the development and cycling of hair follicles.
150 citations,
May 1993 in “The journal of cell biology/The Journal of cell biology” Mouse Notch is important for determining cell roles in hair follicles.
61 citations,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
223 citations,
January 2014 in “International Journal of Molecular Sciences” The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.
85 citations,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
83 citations,
May 2013 in “International Journal of Molecular Sciences” Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.
January 2019 in “Advances in stem cells and their niches” Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
