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research Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin

5 citations , May 2023 in “Frontiers in Cell and Developmental Biology”

This study used single-cell techniques and lineage tracing to reveal that integrin α6 expression in neural crest cells can differentiate them into Schwann cells, melanocytes, and fibroblasts in skin, identifying integrin α6 as a potential marker for these derivatives.

research Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss

January 2008 in “Journal of Clinical Dermatology”

This study found that integrin alpha-6 and p63 may play a role in hair loss, with variable expression patterns in different types of alopecia observed in scalp biopsy samples.

research Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism.

8 citations , February 2024 in “Matrix Biology”

research Testosterone Down-regulates Expression of αVβ3-integrin, E-cadherin and Mucin-1 during Uterine Receptivity Period in Rats

5 citations , October 2018 in “Sains Malaysiana”

This study found that testosterone administration reduced the expression of uterine receptivity molecules in ovariectomized rats, which may negatively affect early pregnancy establishment and female fertility.

research Influence of aerosol bioelectricity on expression of epidermal growth factor and β_1 integrin in healing wounds of burned rats

January 2005 in “Di-san junyi daxue xuebao”

This study found that treatment with aerosol bioelectricity accelerated wound healing in burned rats by enhancing the expression of EGF and β_1 integrin in skin basal and hair follicle cells.

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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