Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells

    Shuang Liu, Huishan Zhang, Enkui Duan
    Studysummary This review explores embryonic epidermal development and discusses key molecular regulators and roles of the sub-epidermal mesenchyme, but reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 31

    1. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    2. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    3. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    4. Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen PLOS ONE · 2012
    5. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012
    6. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    7. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    8. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    9. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    10. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    11. Reassessing K15 as an Epidermal Stem Cell Marker Stem Cell Reviews and Reports · 2011
    12. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    13. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    14. Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma Nature Cell Biology · 2010
    15. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    16. TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis Journal of Cellular and Molecular Medicine · 2009
    17. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009
    18. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008
    19. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    20. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    21. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    22. Scratching the Surface of Skin Development Nature · 2007
    23. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    24. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    25. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    26. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    27. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    28. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    29. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    30. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    31. The Secret Life of the Hair Follicle Trends in genetics · 1992