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    Glossary Sonic hedgehog

    protein crucial for tissue growth and hair follicle development

    Sonic hedgehog (SHH) is a protein that plays a crucial role in regulating the growth and development of various tissues and organs in the body, including hair follicles. It is part of the hedgehog signaling pathway, which is essential for cell differentiation and tissue patterning during embryonic development. Mutations or disruptions in the SHH pathway can lead to developmental disorders and diseases.

    Research 10 of 1000+

    1. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    2. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog Journal of Clinical Investigation · 1999 · 231 citations
    3. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis Development · 2004 · 99 citations
    4. Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog Genes & Development · 2016 · 75 citations
    5. Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis Developmental Biology · 2003 · 53 citations
    6. Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells Cell Death and Disease · 2020 · 52 citations
    7. Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia JNCI: Journal of the National Cancer Institute · 2001 · 39 citations
    8. Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage Journal of Investigative Dermatology · 2014 · 30 citations
    9. Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation FEBS Journal · 2021 · 23 citations
    10. Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo Science Advances · 2023 · 18 citations
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    1. New study suggests hair regrowth on wounded and bald skin may be possible Reddit · 1 Dec 2018

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