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Glossary Sonic hedgehog

protein crucial for tissue growth and hair follicle development

Sonic hedgehog (SHH) is a protein that plays a crucial role in regulating the growth and development of various tissues and organs in the body, including hair follicles. It is part of the hedgehog signaling pathway, which is essential for cell differentiation and tissue patterning during embryonic development. Mutations or disruptions in the SHH pathway can lead to developmental disorders and diseases.

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Research

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research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.

research Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

231 citations , October 1999 in “Journal of Clinical Investigation”

This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.

research An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis

99 citations , September 2004 in “Development”

This study suggests that deregulation of sonic and desert hedgehog signaling in mouse skin can lead to altered epidermal stem cell activity and lesions similar to human basal cell carcinoma, indicating these cancers may originate outside the stem cell population.

research Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

research Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis

53 citations , October 2003 in “Developmental Biology”

This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.

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community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community 20 years old, treatment options?

1 upvotes 6 years ago

A 20-year-old experiencing hair loss had negative side effects from finasteride and cannot afford RU58841 or Minoxidil. Suggestions included dermarolling, hair systems, and possibly using peppermint oil or Saw Palmetto.

community Most Promising Future Hair Loss Treatments In 2026

83 upvotes 1 week ago

Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Hair gel makes my hair look terribly unhealthy?!

in Styling 267 upvotes 1 year ago

Avoid hair gel; use sea salt spray, matte clay, or styling powder for volume. Use finasteride and minoxidil for hair loss.

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