TLDR TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
The study investigated the role of TGF-β2 in hair follicle stem cell (HFSC) activation and its interaction with BMP signaling. Researchers found that TGF-β2, produced by dermal papillae, activated Smad2/3 signaling in HFSCs, counteracting BMP's repressive effects. This balance was crucial for proper hair follicle regulation. Mice unable to sense TGF-β showed delayed hair regeneration, while TGF-β2 injections stimulated HFSC activation. The gene Tmeff1 was identified as a key mediator, acting as a BMP inhibitor. The findings highlighted the importance of TGF-β2 in mesenchymal-epithelial crosstalk necessary for HFSC activation and hair cycle progression, suggesting potential therapeutic targets for hair loss and alopecia.
260 citations,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
479 citations,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
854 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
211 citations,
October 2001 in “The FASEB Journal” Noggin is necessary to start the hair growth phase in skin after birth.
88 citations,
January 2019 in “Journal of Tissue Engineering and Regenerative Medicine” Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.
