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    GlossaryHair Follicle Stem Cells

    specialized cells in hair follicles that regenerate hair and skin

    Hair Follicle Stem Cells (HFSCs) are specialized cells located in the bulge region of hair follicles. They play a crucial role in the growth and regeneration of hair by periodically activating to produce new hair shafts and contribute to the repair of skin injuries. These cells have the unique ability to self-renew and differentiate into various cell types, making them essential for maintaining healthy hair and skin.

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      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

      learn Stemoxydine

      chemical from L'Oreal that encourages hair to enter growth phase

      learn Microneedling

      technique to create small wounds in skin to activate collagen production and hair growth

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      community PP405 - hair stem cell stimulation

      in Research/Science  51 upvotes 8 months ago
      PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 9 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.