Procyanidin

    TLDR bioflavonoid found in plants with antioxidant and hair stimulating properties

    Procyanidin, a class of bioflavonoids found in plants, fruits, and seeds, has gained attention for its potential health benefits, including its role in hair care and growth. These natural compounds are particularly abundant in apples, grapes, and cocoa, known for their antioxidant properties. Beyond their general health benefits, procyanidins have been explored for their potential to stimulate hair growth and improve hair health, making them a subject of interest for those experiencing alopecia and seeking natural treatment options.

    Procyanidin is a member of the polyphenol family and is an oligomeric flavonoid with antioxidant, antihypertensive, capillary protective, and elastase inhibitor effects. These effects are linked to its influence on cytokines that regulate the hair cycle, promoting positive regulators like IGF-1 and VEGF, while inhibiting negative ones such as TGF-β, which is associated with hair growth inhibition and keratinocyte apoptosis. Procyanidin B2 dimer counteracts TGF-β’s effects, promoting cell survival and proliferation through MEK activation and reducing protein kinase C expression, a known inhibitor of hair growth.

    The interest in procyanidin's role in alopecia, hair loss, or growth also stem from its purported ability to promote hair follicle health and the anagen phase of the hair growth cycle. Research on procyanidin B2, especially, has shown promising results in this regard. A randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of topical procyanidin B2 on men with androgenetic alopecia (AGA) revealed significant increases in hair count and thickness, suggesting that procyanidin B2 can be an effective and safe treatment for male pattern baldness.

    Within the community, sentiments and experiences regarding procyanidin-based treatments for hair loss are generally positive. Individuals share their success stories using products infused with procyanidin, noting improvements in hair density, scalp health, and overall hair appearance. These anecdotal reports often highlight procyanidin B2, extracted from apples.

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