Procyanidin
🛒 Where to find Procyanidin
Tracking 1 topical product by companies like The Revivogen MD . View product »Procyanidin, a class of bioflavonoids found in plants, fruits, and seeds, has gained attention for its potential health benefits, including its role in hair care and growth. These natural compounds are particularly abundant in apples, grapes, and cocoa, known for their antioxidant properties. Beyond their general health benefits, procyanidins have been explored for their potential to stimulate hair growth and improve hair health, making them a subject of interest for those experiencing alopecia and seeking natural treatment options.
Procyanidin is a member of the polyphenol family and is an oligomeric flavonoid with antioxidant, antihypertensive, capillary protective, and elastase inhibitor effects. These effects are linked to its influence on cytokines that regulate the hair cycle, promoting positive regulators like IGF-1 and VEGF, while inhibiting negative ones such as TGF-β, which is associated with hair growth inhibition and keratinocyte apoptosis. Procyanidin B2 dimer counteracts TGF-β’s effects, promoting cell survival and proliferation through MEK activation and reducing protein kinase C expression, a known inhibitor of hair growth.
The interest in procyanidin's role in alopecia, hair loss, or growth also stem from its purported ability to promote hair follicle health and the anagen phase of the hair growth cycle. Research on procyanidin B2, especially, has shown promising results in this regard. A randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of topical procyanidin B2 on men with androgenetic alopecia (AGA) revealed significant increases in hair count and thickness, suggesting that procyanidin B2 can be an effective and safe treatment for male pattern baldness.
Within the community, sentiments and experiences regarding procyanidin-based treatments for hair loss are generally positive. Individuals share their success stories using products infused with procyanidin, noting improvements in hair density, scalp health, and overall hair appearance. These anecdotal reports often highlight procyanidin B2, extracted from apples.
Research
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research Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo
research Procyanidin B-2 Extracted from Apples Promotes Hair Growth: A Laboratory Study
research Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1
research Investigation of Topical Application of Procyanidin B-2 from Apple to Identify Its Potential Use as a Hair Growing Agent
research Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth
research Toxicological Studies on Procyanidin B-2 for External Application as a Hair Growing Agent
research Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent
research The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent
research Procyanidins Attenuate Neuropathic Pain by Suppressing Matrix Metalloproteinase-9/2
research Procyanidin Oligomers Counteract TGF-β1- and TGF-β2-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms
research African Baobab (Adansonia Digitata) Fruit as a Promising Source of Procyanidins
research Procyanidin B-2 and the Hair-Growing Activity of Proanthocyanidins
research Progress on Study of Pharmacological Effects of Procyanidins
research Studies on the Biological Actions of Procyanidins and Phosphatidic Acids on Hair Follicles: Experimental Approaches
research Evaluation of the Efficacy and Safety of Topical Procyanidin B2 and Placebo in the Treatment of Androgenetic Alopecia in Men: A Randomized, Double-Blind, Placebo-Controlled Study
research Oligomeric Procyanidins in Apple Polyphenol Are Main Active Components for Inhibition of Pancreatic Lipase and Triglyceride Absorption
research A Semisynthetic Approach for the Simultaneous Reaction of Grape Seed Polymeric Procyanidins with Catechin and Epicatechin to Obtain Oligomeric Procyanidins in Large Scale
research Biological Actions of Oligomeric Procyanidins: Proliferation of Epithelial Cells and Hair Follicle Growth
