Procyanidins Attenuate Neuropathic Pain by Suppressing Matrix Metalloproteinase-9/2

    June 2018 in “ Journal of Neuroinflammation ”
    Cailong Pan, Chaoyu Wang, Li Zhang, Ling Song, Yuan Chen, Bingqian Liu, Wentao Liu, Liang Hu, Yinbing Pan
    Image
    Studysummary This study found that procyanidins effectively alleviate neuropathic pain in mice by significantly inhibiting MMP-9/2 activity.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study found that procyanidins, a natural product extracted from grape seed, can alleviate neuropathic pain via the inhibition of matrix metalloproteinase (MMP)-9/2 and the maturation of IL-1ß. The study was conducted on mice and found that PC directly inhibited the activity of MMP-9/2 in vitro. Additionally, PC blocked the maturation of interleukin-1ß, which is a critical substrate of MMPs, and markedly suppressed CCI-induced MAPK phosphorylation and neuronal and microglia activation. The study suggests that PC may be a potential therapeutic agent for neuropathic pain.
    Discuss this study in the Community →