Procyanidins Attenuate Neuropathic Pain by Suppressing Matrix Metalloproteinase-9/2

    June 2018 in “ Journal of Neuroinflammation ”
    Cailong Pan, Chaoyu Wang, Li Zhang, Ling Song, Yuan Chen, Bingqian Liu, Wentao Liu, Liang Hu, Yinbing Pan
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    TLDR Procyanidins from grape seeds reduce nerve pain by blocking specific proteins and inflammation.
    The study found that procyanidins, a natural product extracted from grape seed, can alleviate neuropathic pain via the inhibition of matrix metalloproteinase (MMP)-9/2 and the maturation of IL-1ß. The study was conducted on mice and found that PC directly inhibited the activity of MMP-9/2 in vitro. Additionally, PC blocked the maturation of interleukin-1ß, which is a critical substrate of MMPs, and markedly suppressed CCI-induced MAPK phosphorylation and neuronal and microglia activation. The study suggests that PC may be a potential therapeutic agent for neuropathic pain.
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