Procyanidin B-2 Extracted from Apples Promotes Hair Growth: A Laboratory Study

    Ayako Kamimura, Tomoya Takahashi
    Studysummary This study found that procyanidin B-2 may promote hair growth by reducing expression and inhibiting translocation of PKC isozymes in murine hair epithelial cells.
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    Research cited in this study 6

    1. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001
    2. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth Skin pharmacology and physiology · 2000
    3. Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion Journal of Cell Science · 1999
    4. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1999
    5. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997
    6. Bisindolylmaleimide Protein Kinase C Inhibitors Delay the Decline in DNA Synthesis in Mouse Hair Follicle Organ Cultures Skin Pharmacology and Physiology · 1997

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