The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse

October 2021 in “ Research Square (Research Square) ”

Keonwoo Choi, Sanghee Park, Seo‐Yeon Park, Sungjoo Kim Yoon

TLDR Hair follicle stem cells in hairpoor mice are disrupted, causing hair loss.

The study on the hairpoor mouse, an MUHH model, reveals that hair follicle stem cell (HFSC) quiescence is disrupted, leading to a disturbed hair cycle and alopecia. After the 1st telogen stage, hair follicles drastically decrease, and HFSCs show reduced quiescence and increased proliferation. Key signaling molecules like Fgf18, Bmp6, and Wnt are misregulated, causing accelerated hair cycling and transition from telogen to anagen. These findings help explain the progression of alopecia in MUHH patients.

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