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GlossaryHair Follicle Stem Cells (HFSC)

specialized cells in hair follicles that regenerate hair and skin

Hair Follicle Stem Cells (HFSCs) are specialized cells located in the bulge region of hair follicles. They play a crucial role in the growth and regeneration of hair by periodically activating to produce new hair shafts and contribute to the repair of skin injuries. These cells have the unique ability to self-renew and differentiate into various cell types, making them essential for maintaining healthy hair and skin.

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Feasibility of Repairing Skin Defects by VEGF165 Gene-Modified iPS-HFSCs Seeded on a 3D Printed Scaffold Containing Astragalus Polysaccharide

research Feasibility of Repairing Skin Defects by VEGF165 Gene-Modified iPS-HFSCs Seeded on a 3D Printed Scaffold Containing Astragalus Polysaccharide

1 citations, June 2023 in “Journal of Cellular and Molecular Medicine”

The new method using gene-modified stem cells and a 3D printed scaffold improved skin repair in mice.

research Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation

September 2019 in “Journal of Investigative Dermatology”

BMPs are important for hair growth and can counteract the negative effects of androgens on hair follicle stem cells.

research Synergism Between Tocotrienol and Injectable Platelet-Rich Fibrin in Hair Follicle Stem Cells Proliferation: An In Vitro Study

July 2023 in “Research Square (Research Square)”

Aloe Vera and injectable platelet-rich fibrin (i-PRF) together can speed up and improve hair growth when used in the right amounts.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations, May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations, January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 2 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Horrible news, Stemson Therapeutics has shut down

in Technology 193 upvotes 1 week ago

Stemson Therapeutics has shut down, disappointing those seeking a hair loss cure. Current treatments like minoxidil, finasteride, and dutasteride are discussed, with some users experiencing side effects and exploring alternatives like PP405.

community 21 y/o M, 3 month amazing progress on min and topical fin, I want to share my success story.

in Progress Pictures 141 upvotes 3 years ago

A 21-year-old male who has been suffering from hair loss since he was 17, and has made great progress with a combination of minoxidil and finasteride topical solutions. They discussed the efficacy of microneedling for sensitive scalps as well.

community TDM-105795 phase 2 results are in!

in Research/Science 28 upvotes 10 months ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.