TLDR The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.
The document from 2012 discusses the role of signaling pathways, specifically BMP, WNT, FGF, and TGF-ß, in the regulation of the hair cycle, focusing on the transition from telogen to anagen phases. It reveals that Fgf18 and Tgf-ß2 signaling are critical in timing the hair cycle, with Fgf18 maintaining telogen phase and Tgf-ß2 delaying anagen initiation. The paper also explores the hair follicle's microenvironment and macroenvironment, as well as inter-follicular communication. It suggests that analyzing long-term hair growth patterns can help understand hair cycle defects, which is particularly relevant in androgenic alopecia where the anagen phase is shortened. The document concludes by proposing Fgf18 and Tgf-ß signaling as potential therapeutic targets for hair loss treatments, emphasizing the importance of further research into how these pathways regulate the hair cycle within stem cell niches.
Cited in this study
8 / 8 results
21 citations
,
March 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” Telogen is an active phase with important biological processes, not a resting phase.
321 citations
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January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
499 citations
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September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
176 citations
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April 2011 in “Science” Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.
235 citations
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February 2011 in “Journal of Clinical Investigation” Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.
314 citations
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April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
384 citations
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June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
211 citations
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October 2001 in “The FASEB Journal” Noggin is necessary to start the hair growth phase in skin after birth.
36 citations
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October 2015 in “Cell reports” Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
68 citations
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May 2012 in “Journal of Investigative Dermatology” The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.
260 citations
,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
314 citations
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April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.