Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

    October 2015 in “ Cell reports ”
    Özlem Akilli Öztürk, Hubert Pakula, Jolanta Chmielowiec, Jingjing Qi, Simone Stein, Linxiang Lan, Yoshiyuki Sasaki, Klaus Rajewsky, Walter Birchmeier
    Studysummary In this study, researchers found that Gab1 is critical in controlling the hair cycle and the self-renewal of hair follicle stem cells in mice. Our plain-language summary of this paper — not a Tressless recommendation.
    The study concluded that Gab1 and MAPK signaling were essential for regulating the hair cycle and maintaining hair follicle stem cell quiescence. Conditional Gab1 mutant mice showed disrupted hair cycle progression, failing to enter catagen, leading to continuous proliferation and eventual exhaustion of stem cells. Gab1 functioned downstream of receptor tyrosine kinases and upstream of Shp2 and MAPK signaling pathways. Activation of MAPK signaling could rescue hair cycle deficits and restore stem cell quiescence in mutants, highlighting the critical roles of Gab1, Shp2, and MAPK signaling in hair follicle regulation and stem cell maintenance.
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