TLDR Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
The study concluded that Gab1 and MAPK signaling were essential for regulating the hair cycle and maintaining hair follicle stem cell quiescence. Conditional Gab1 mutant mice showed disrupted hair cycle progression, failing to enter catagen, leading to continuous proliferation and eventual exhaustion of stem cells. Gab1 functioned downstream of receptor tyrosine kinases and upstream of Shp2 and MAPK signaling pathways. Activation of MAPK signaling could rescue hair cycle deficits and restore stem cell quiescence in mutants, highlighting the critical roles of Gab1, Shp2, and MAPK signaling in hair follicle regulation and stem cell maintenance.
479 citations,
June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
52 citations,
October 2012 in “Journal of Dermatological Science” The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.
191 citations,
September 2011 in “Cell stem cell” Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
107 citations,
June 1997 in “PubMed” EGFR is essential for normal hair development and follicle differentiation.
21 citations,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
21 citations,
May 2016 in “Experimental and Therapeutic Medicine” MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
April 2016 in “Journal of Investigative Dermatology” Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
